Sunday, September 30, 2012

Research Associate Population Genomics of Emerging Infections

Imperial College London -Department of Infectious Disease Epidemiology

School of Public Health
Salary Range £28,200 - £40,720 per annum
Applications are invited to join the Department of Infectious Disease Epidemiology located at the St Mary's campus, Paddington. The department is based within a five star research institute equipped with the latest technologies and facilities. DIDE is arguably the largest grouping of infectious disease epidemiologists in the world with a very wide range of skills represented, from experimental studies on bacterial/fungal pathogens, through population genetics and infectious disease modelling to field work on emerging infectious disease. As such, the Department offers excellent research facilities and a friendly, intellectually stimulating, working environment.
Emerging fungal infections are attracting increasing scientific and policy interest as their impact on human and ecosystem health becomes more pronounced (see Nature 484 2012). This Research Associate post is funded by a 3-year MRC project grant, entitled 'An evolutionary population genomics approach to determine the genetic basis of virulence in the pathogenic fungus Cryptococcus neoformans', and seeks to understand the evolutionary basis underlying this pathogen's emergence as a leading cause of human disease in Africa and South East Asia.
The post holder will join a multidisciplinary team of researchers that are using statistical genetic and functional genomic approaches to identify the patterns and processes that have led to contemporary distributions of genetic diversity for emerging pathogenic fungi, with a focus on Cryptococcus. The post-holder will have a key role in study design and will develop a state-of-the-art bioinformatics pipeline for assembling next-generation sequence data from a global panel of environmental and clinical Cryptococcus isolates. These data will be used for statistical genetic, phylodynamic and evolutionary analyses with the ultimate goal of defining the subset of genetic diversity that is associated with virulence and spatial-expansion of key lineages of Cryptococcus. Key responsibilities will be to develop cutting-edge approaches to managing large eukaryote population genomics datasets, and to liaise with our international collaborators in order to effectively share and curate genome-data.
The successful candidate will have a strong bioinformatic, evolutionary or statistical genetics background with a PhD degree or equivalent in a relevant quantitative subject.
This post is a full time and fixed term until 31st July 2015.
For informal enquiries please contact Dr. Matthew Fisher (matthew.fisher@imperial.ac.uk).
Our preferred method of application is online via our website. Please complete and upload an application form as directed.
Reference number: SM151-12
Closing date: 21 October 2012
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